5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclin-dependent kinase 4 and cytotoxic agents

C K Ryu; H Y Kang; S K Lee; K A Nam; C Y Hong; W G Ko; B H Lee

doi:10.1016/s0960-894x(00)00014-7

5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclin-dependent kinase 4 and cytotoxic agents

Bioorg Med Chem Lett. 2000 Mar 6;10(5):461-4. doi: 10.1016/s0960-894x(00)00014-7.

Authors

C K Ryu¹, H Y Kang, S K Lee, K A Nam, C Y Hong, W G Ko, B H Lee

Affiliation

¹ College of Pharmacy, Ewha Womans University, Seoul, South Korea. ckryu@mm.ewha.ac.kr

PMID: 10743948
DOI: 10.1016/s0960-894x(00)00014-7

Abstract

5-Arylamino-2-methyl-4,7-dioxobenzothiazoles were synthesized as inhibitors of cyclin-dependent kinase 4 (CDK4) and cytotoxic agents. Most of the 4,7-dioxobenzothiazoles exhibited selective inhibitory activities for the CDK4 and cytotoxic potential against human cancer cell lines.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / pharmacology
Cyclin-Dependent Kinase 4
Cyclin-Dependent Kinases / antagonists & inhibitors*
Enzyme Inhibitors / chemical synthesis*
Enzyme Inhibitors / pharmacology
HL-60 Cells
Humans
Proto-Oncogene Proteins*
Thiazoles / chemical synthesis*
Thiazoles / pharmacology
Tumor Cells, Cultured

Substances

Antineoplastic Agents
Enzyme Inhibitors
Proto-Oncogene Proteins
Thiazoles
CDK4 protein, human
Cyclin-Dependent Kinase 4
Cyclin-Dependent Kinases